Ospedale San Raffaele

OSR is the leading private scientific research Institute in Italy, recognized by the Italian Ministry of Health as a Research Hospital (IRCCS). It comprises both clinical and research activities, conducted within a highly specialized and qualified Hospital with 1,357 beds and a research Institute with around 1,600 basic, clinical and translational scientists. The premises also host the Vita-Salute San Raffaele University (USR), which comprises the faculties of medicine, psychology and philosophy and provides specialized post-graduate courses, residency programs in various medical specialties, and International PhD programs. OSR performs cutting-edge science and aims at advancing the knowledge about human diseases and developing novel therapies through translational research. In particular OSR expertise-excellence areas are: Oncology; Neuroscience; Metabolic and Cardiovascular Sciences; Regenerative Medicine, Stem Cells and Gene Therapy; Immunology, Transplantation and Infectious Diseases; Genetics and Cell Biology; Genomics, Bioinformatics and Imaging technologies.

As Work Package leader of WP1, OSR is responsible for the design and generation of biologically improved CAR T-cells. OSR will lead the efforts in the optimisation of protocols for genetically modifying early-differentiated memory T cells, which are known to be endowed with superior antitumor activity. OSR will also drive the validation of improved CAR T-cell safety and efficacy in innovative xenograft models. Additionally, OSR will participate to the validation of the conditions for GMP manufacturing of improved CAR-T cells, with the ultimate goal of clinical translation.

Team members

Photo of Monica Casucci
Monica Casucci
Team Leader
Photo of Silvia Arcangeli
Silvia Arcangeli
Deputy Team Leader
Photo of Marta Moresco
Marta Moresco
Project and grant manager

Ospedale San Raffaele
Via Olgettina 60
20132 Milan