Ospedale San Raffaele
OSR is the leading private scientific research Institute in Italy, recognized by the Italian Ministry of Health as a Research Hospital (IRCCS). It comprises both clinical and research activities, conducted within a highly specialized and qualified Hospital with 1,357 beds and a research Institute with around 1,600 basic, clinical and translational scientists. The premises also host the Vita-Salute San Raffaele University (USR), which comprises the faculties of medicine, psychology and philosophy and provides specialized post-graduate courses, residency programs in various medical specialties, and International PhD programs. OSR performs cutting-edge science and aims at advancing the knowledge about human diseases and developing novel therapies through translational research. In particular OSR expertise-excellence areas are: Oncology; Neuroscience; Metabolic and Cardiovascular Sciences; Regenerative Medicine, Stem Cells and Gene Therapy; Immunology, Transplantation and Infectious Diseases; Genetics and Cell Biology; Genomics, Bioinformatics and Imaging technologies.
As Work Package leader of WP1, OSR is responsible for the design and generation of biologically improved CAR T-cells. OSR will lead the efforts in the optimisation of protocols for genetically modifying early-differentiated memory T cells, which are known to be endowed with superior antitumor activity. OSR will also drive the validation of improved CAR T-cell safety and efficacy in innovative xenograft models. Additionally, OSR will participate to the validation of the conditions for GMP manufacturing of improved CAR-T cells, with the ultimate goal of clinical translation.